Skip to main content
. 2021 Feb 1;9(2):e001580. doi: 10.1136/jitc-2020-001580

Table 1.

Ongoing sarcoma immunotherapy clinical trials

Paradigm Intervention Disease Status Clinical trial ID Locations
Adoptive cell transfer TIL
IL-2
Fludarabine
Cyclophosphamide
High grade STS Phase I, Recruiting NCT04052334 USA
NY-ESO-1c259T cells Myxoid/round cell liposarcoma Phase II, Recruiting NCT02992743 USA
Engineered NY-ESO-1 (GSK3377794) T cells
Fludarabine
Cyclophosphamide
Synovial Sarcoma Phase II, Recruiting NCT03967223 USA
ADP-A2M4 SPEAR anti-MAGE-A4 T cells Synovial Sarcoma,
Myxoid/round cell liposarcoma
Phase II, Recruiting NCT04044768 USA
CAR T cells Anti-GD2 (C7R-GD2.CAR) T cells
Fludarabine
Cyclophosphamide
Relapsed OS, relapsed Ewing’s sarcoma, relapsed RMS Phase I, Recruiting NCT03635632 USA
Autologous anti-HER-2 CAR T
Fludarabine
Cyclophosphamide
STS Phase I, Active NCT00902044 USA
Vaccines Tumor lysate loaded DC Vaccine
Gemcitabine
Imiquimod
STS, Bone sarcoma Phase I, Active NCT01803152 USA
GVAX Clear Cell Sarcoma,
Alveolar Soft Part sarcoma
Phase I, Active NCT00258687 USA
MVA expressing p53 STS Phase I, Active NCT02432963 USA
Adoptive NK cell therapy NK cell infusion HSCT RMS Phase I, II, Completed NCT01386619 Germany
Switzerland
NK cell infusion and recombinant IL-15 Sarcoma Phase I,
Completed
NCT01875601 USA
Expanded, activated NK cells Ewing Sarcoma, RMS Phase I, II, Recruiting NCT02409576 Singapore
NK cell infusion HSCT Ewing Sarcoma, OS, RMS, STS Phase II, Active, not recruiting NCT01807468 South Korea

CAR, chimeric antigen receptor; DC, dendritic cell; GD2, disialoganglioside; HSCT, hematopoietic stem cell transplantion; IL-15, interleukin 15; MVA, modified vaccinia Ankara; OS, osteosarcoma; RMS, rhabdomyosarcoma; STS, soft-tissue sarcoma; TIL, tumor infiltrating lymphocyte.