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. 2020 Aug 19;28(1):283–302. doi: 10.1038/s41418-020-0600-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — CircRNA-vgll3-modified ADSCs composition with CPC scaffolds promote the repair of critical-sized bone defects. CircRNA-vgll3 directly sequesters miR-326-5p in the cytoplasm and inhibits its activity, which in turn upregulates the protein levels of Itga5. The upregulated Itga5 protein levels help mediate the homing of ADSCs to the bone, the recruitment of osteoprogenitor cells, and the promotion of osteogenic differentiation in ADSCs.