Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 13;28(1):123–138. doi: 10.1038/s41418-020-0587-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a Percentage of the ratio of the metabolic activity (MTS assay) of WT and SEPN1 KO HeLa cells between 2 days of culture in low glucose (5.5 mM) and high glucose (25 mM) (N = 9). b Measurement of cellular ATP content in WT and SEPN1 KO HeLa cells. Results from three independent experiments are summarized as a graph (N = 6). c Analysis of mitochondrial membrane potential (Ψm) as measured by TMRM intensity in WT and SEPN1 KO HeLa cells (N = 34). d Mitochondrial respiratory chain specific activity in WT and SEPN1 KO C2C12 (N = 4). e Oxygraphy studies of mitochondrial complexes in tibialis anterior and diaphragm muscles from Sepn1 KO mice (red bars) compared with WT animals (black bars). f Complex I activity in tibialis anterior (TA), diaphragm (DF), quadriceps (QD), and extensor digitorum longus (EDL).