Fig. 3. Patterns of genomic variants in tumours in each subgroup.

a Number of small non-synonymous exonic variants in each tumour sample in the validation set analysed by whole-exome sequencing. b Pathogenic variants in selected Wilms tumour-related genes in the validation set analysed by whole-exome sequencing. Each column represents one tumour. Black boxes indicate a pathogenic mutation in the denoted gene in that tumour. c Number of segmental chromosomal aberrations per tumour sample in the discovery set.