Fig. 4. Strategy for choriocapillaris (CC) analysis in eyes with intermediate AMD.

Protocol for spectral domain excluding the drusen and the superficial capillary plexus. En face optical coherence tomography angiography (OCTA) slabs of the choriocapillaris (A) and the superficial capillary plexus (B), as well as the retinal pigment epithelium (RPE) elevation map (C) are exported. The superficial retinal vessels and the RPE elevation map (indicative of regions of drusen or pigment epithelial detachment) are used to create a mask (D, E, respectively) which is applied to the OCTA image to exclude regions which may be confounded by signal attenuation or residual projection artifacts from the analysis (F).