Fig. 2.

Bcl10 deficiency in Treg cells leads to lethal autoimmune inflammation. a Image of 24-day-old littermate female mice with different genotypes: Bcl10^+/+Foxp3^cre, Bcl10^fl/+Foxp3^cre, or Bcl10^fl/flFoxp3^cre. b Survival of Bcl10^+/+Foxp3^cre, Bcl10^fl/+Foxp3^cre, and Bcl10^fl/flFoxp3^cre mice (n = 9, 17, and 8 per group, respectively). c Images of the thymus, spleen, inLN (inguinal lymph node), axLN (axillary lymph node), scLN (superficial neck lymph node), and colon harvested from 24-day-old female littermate mice with different genotypes: Bcl10^+/+Foxp3^cre, or Bcl10^fl/flFoxp3^cre. d Colon length in 24-day-old Bcl10^+/+Foxp3^cre, and Bcl10^fl/flFoxp3^cre mice (n = 7 or 6 per group). e H&E staining of the skin of the ear and tail and tissue samples from the liver, kidney, lung, and colon from 24-day-old mice with different genotypes: Bcl10^+/+Foxp3^cre, or Bcl10^fl/flFoxp3^cre. f Enzyme-linked immunosorbent assay (ELISA) analysis of IgE, TNFα, IL-6, and IL-1β levels in serum samples obtained from Bcl10^+/+Foxp3^cre (n = 8) or Bcl10^fl/flFoxp3^cre (n = 7) mice on day 24. Student’s t test was used as the statistical test (*p < 0.05, **p < 0.01, and ***p < 0.005). All error bars represent SDs