Table 3.
Multivariate regression analysis for log-(HOMA-IR) according to FHD.
| All | Females | Males | ||||
|---|---|---|---|---|---|---|
| Variables | β | P | β | P | β | P |
| A. Individuals with FHD, n | 1,150 | 852 | 298 | |||
| Age, years | −0.10 | <.001 | −0.10 | .0497 | −0.08 | .14 |
| Body mass index, kg/m2 | 0.39 | <.001 | 0.37 | <.001 | 0.41 | <.001 |
| Waist circumference, cm | 0.20 | <.001 | 0.18 | <.001 | 0.21 | .019 |
| Females | 0.06 | .069 | — | — | — | — |
| Pack-years of smoking | 0.01 | .72 | 0.02 | .56 | 0.002 | .96 |
| Ethanol, g/d | −0.04 | .17 | −0.01 | .71 | −0.04 | .39 |
| Activity count, /minute | −0.09 | <.001 | −0.06 | .032 | −0.13 | .008 |
| Menopause | — | — | −0.01 | .81 | — | — |
| Hypertension | 0.09 | <.001 | 0.09 | .002 | 0.08 | .12 |
| Log-(Acti-ODI3%) | 0.06 | .058 | 0.13 | <.001 | −0.10 | .055 |
| R2 (adjusted R2), % | 36.2 (36.0) | 40.2 (39.6) | 40.9 (39.2) | |||
| B. Individuals without FHD, n | 4,586 | 3,112 | 1,474 | |||
| Age, years | −0.10 | <.001 | −0.11 | <.001 | −0.10 | <.001 |
| Body mass index, kg/m2 | 0.40 | <0.001 | 0.41 | <.001 | 0.34 | <.001 |
| Waist circumference, cm | 0.20 | <0.001 | 0.16 | <.001 | 0.26 | <.001 |
| Females | 0.06 | 0.001 | — | — | — | — |
| Pack-years of smoking | 0.01 | 0.56 | −0.03 | .08 | 0.01 | .60 |
| Ethanol, g/d | −0.07 | <0.001 | −0.03 | .02 | −0.11 | <.001 |
| Activity count, /minute | −0.07 | <0.001 | −0.06 | <.001 | −0.07 | <.001 |
| Menopause | — | — | 0.01 | .59 | — | — |
| Hypertension | 0.09 | <0.001 | 0.10 | <.001 | 0.06 | .011 |
| Log-(Acti-ODI3%) | 0.02 | 0.19 | 0.01 | .68 | 0.02 | .31 |
| R2 (adjusted R2), % | 36.4 (36.3) | 34.7 (34.5) | 39.4 (39.1) | |||
Acti-ODI3% = 3% oxygen desaturation index modified by sleep duration derived from actigraphy; FHD = family history of diabetes; HOMA-IR = homeostatic model assessment–insulin resistance; β = standardized partial regression coefficient.