Table 1:

Expected biochemical and clinical sequelae of treatments for primary aldosteronism including: curative adrenalectomy for unilateral disease, non-curative unilateral adrenalectomy for bilateral disease, MR antagonist therapy, and dietary sodium restriction.

Parameters	Curative Adrenalectomy for Unilateral Disease	Non-curative Unilateral Adrenalectomy for Bilateral Disease	MR Antagonist Therapy	Dietary Sodium Restriction
Aldosterone	↓↓	↓	↑	↑
Renin	↑↑	↑↑	↑↑	↑
ARR	↓↓	↓	↓	↓
Potassium	↑	↑	↑	↑
Base Excess/ Alkalosis	↓	↓	↓	↓
eGFR	↓	↓	↓	↓
Blood Pressure	↓↓	↓	↓	↓
Risk for Incident Cardiovascular and Kidney Disease	↓*	unknown	↓*	↓#

^*Observations from longitudinal cohort studies comparing curative adrenalectomy with MR antagonist therapy

^#Observations from population-based studies evaluating dietary sodium restriction in essential hypertension