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. Author manuscript; available in PMC: 2022 Jan 20.
Published in final edited form as: J Am Chem Soc. 2021 Jan 7;143(2):623–627. doi: 10.1021/jacs.0c11113

Figure 2. Crystal structure of compound 1 bound to E. coli PheRS explains structure-activity relationships.

Figure 2.

Cartoon and stick representations of two E. coli PheRS structures are overlain. The crystal structure of E. coli PheRS bound to phenylalanine and AMP (PDB #3PCO7) is colored cyan with residues at sites of resistance mutations shown as purple sticks. The structure of E. coli PheRS bound to compound 1 (salmon), is colored grey.