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. Author manuscript; available in PMC: 2022 Jan 20.
Published in final edited form as: J Am Chem Soc. 2021 Jan 7;143(2):623–627. doi: 10.1021/jacs.0c11113

Table 2.

Activity against E. coli cells and PheRS

graphic file with name nihms-1661447-t0002.jpg
Cpd X Y R MIC, μg/mL IC50, μg/mL
1 CH2 H H 12 3.5
2 CH((±)-CH3) H H > 100 93
3 CH2CH2 H H > 100 > 100
4 CH2 o-Me H 17 4.5
5 CH2 m-Me H > 100 > 100
6 CH2 p-Me H > 100 > 100
7 CH2 o,o-diMe H > 100 > 100
8 CH2 H (S)-Me 8 0.7
9 CH2 H (R)-Me > 100 > 100
10 CH2 o-OH (±)-Me 10 4.4