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. 2021 Jan 29;13:861–870. doi: 10.2147/CMAR.S270790

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© 2021 Wang et al.

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Circ_0000429 could bind with miR-1197. (A) The location of circ-0000429 in subcellular. (B) Circ_0000429 predominantly resides in the cytoplasm of lung adenocarcinoma cells. (C) ENCORI, Starbase, and Circular RNA interactome databases were used to predict the miRNA target of circ_0000429. (D) Luciferase activities of circ_0000429-WT and circ_0000429-Mutant after transfection with miR‐1197 mimic/miR-NC. n= 3. (E) Binding situation between circ_0000429 and miR-1197 verified using RNA pull-down. (F) Circ_0000429 in cell lysis was pulled down and collected with a circ_0000429-specific probe and then measured using qRT-PCR. miR-1197 was pulled down and collected with a circ_0000429-specific probe and then evaluated using qRT-PCR. n=3. (G) Co-localization between circ_0000429 and miR-1197 was revealed by fluorescence in situ hybridization. *P<0.05, **P<0.01.