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. 2021 Jan 29;13:861–870. doi: 10.2147/CMAR.S270790

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© 2021 Wang et al.

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MiR-1197 binds with 3ʹUTR of MADD. (A) Four databases (PITA, TargetScan, miRmap, and microT) were used to predict the target of miR-1197. (B) Luciferase activities of MADD-WT and MADD-Mutant after transfection with miR‐1197 mimic/miR-NC. n= 3. (C) The expression of MADD in A549, H2170, SPC-A-1, PG49, Beas-2B was indicated as a control. n=9. (D) MADD in cell lysis was pulled down and collected with a MADD-specific probe and then measured using qRT-PCR. miR-1197 was pulled down and collected with a MADD-specific probe and then evaluated using qRT-PCR. n=3. (E and F) The mRNA (n=9) and protein (n=5) expression of MADD in A549 cells. (G) A positive correlation between circ_0000429 and MADD expression was observed in the NSCLC tissues. A negative correlation between MADD and miR-1197 expression was observed in the NSCLC tissues. n=56. *P<0.05.