Figure 3.

Mean pain intensity over time scored with the observational Face, Legs, Activity, Cry, and Consolability scale (A) following a single dose of tapentadol oral solution, (B) following a single dose of intravenous tapentadol, (C) prior to each intake of tapentadol oral solution (first seven intakes, multiple dose trial).

Notes: (A and B) Missing data were not imputed. Predose scores are displayed at 15 min prior to dosing; data points at each observation time are slightly offset to enhance readability. The intervals show the mean value ± standard deviation; in some cases, there was a high standard deviation exceeding the mean value and this resulted in negative numbers for mean value - standard deviation. (B) ^aPain values were not available for one patient. (C) ^bAssessment was performed 30–60 mins after first intake of trial medication.