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. Author manuscript; available in PMC: 2021 Aug 3.
Published in final edited form as: Adv Drug Deliv Rev. 2020 Aug 3;157:118–141. doi: 10.1016/j.addr.2020.07.026

Figure 4. Schematic illustration of intracellular trafficking related to drug delivery.

Figure 4.

After cellular uptake, DDS are usually transported to endosomes, which act as a sorting center for intracellular transport. DDS can be further transcytosed, exit endosomes (with assistance), or be passively or actively targeted to lysosomes. DDS that exit endosomes may be further targeted to other compartments such as mitochondria and ER. Lys: Lysosomes. This schematic was created with BioRender.com