Table 2. Epidemiologic and clinical characteristics of index recipients associated with SARS-CoV-2 transmission in recipients of solid-organ transplants, United States, March–May 2020*.
Index recipient | Donor | Organ | Symptoms | No. days from transplant to symptom onset | Exposure to persons with COVID-19 | No. days in hospital† | No. days in ICU‡ | No. days intubated‡ | COVID-19 treatment | Immunosuppressive medications, induction | Immunosuppressive medications, maintenance | Patient status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
A |
A |
Bilateral lungs |
Fever, respiratory failure, diaphoresis, atrial fibrillation, shock, acute kidney failure |
6 |
Confirmed COVID-19 among HCW contacts, potential nosocomial transmission |
109 |
35 |
41 |
Hydroxychloroquine, azithromycin |
Basiliximab, methylprednisolone |
Mycophenolate, tacrolimus, prednisone |
Alive |
B |
B |
Single lung |
Fever, nasal congestion |
14 |
Confirmed COVID-19 among HCW contacts |
31 |
None |
None |
Hydroxychloroquine |
Basiliximab, methylprednisolone |
Mycophenolate, tacrolimus, prednisone |
Alive |
C |
C |
Liver |
Altered mental status, fever, respiratory failure |
9 |
Confirmed COVID-19 among household contacts |
79 |
66 |
64 |
Convalescent plasma |
Basiliximab |
Everolimus, prednisone |
Dead |
D |
D |
Liver |
Cough |
7 |
Suspected nosocomial transmission at transplant center |
49 |
19 |
19 |
Hydroxychloroquine, azithromycin |
Methylprednisolone |
Tacrolimus, mycophenolate mofetil, prednisone |
Dead |
E |
E |
Bilateral lungs |
None |
Asymptomatic |
Confirmed COVID-19 among HCW contacts |
17 |
4 |
2 |
Chloroquine |
Basiliximab, methylprednisolone, mycophenolate mofetil |
Tacrolimus, mycophenolate mofetil, prednisone |
Alive |
F |
F |
Single lung |
Fever, dyspnea, wheezing |
7 |
Suspected nosocomial transmission at transplant center |
14 |
14 |
9 |
Remdesivir, azithromycin, intravenous immunoglobulin |
Basiliximab |
Tacrolimus, mycophenolate mofetil, prednisone |
Dead |
G |
G |
Heart and single kidney |
Tachycardia, respiratory failure |
81 |
Confirmed COVID-19 among household contacts |
10 |
9 |
7 |
Hydroxychloroquine, azithromycin |
Basiliximab, methylprednisolone |
Tacrolimus, mycophenolate mofetil, prednisone |
Alive |
H | H | Heart | Dyspnea, fever, diarrhea | 9 | Suspected nosocomial transmission at transplant center | 84 | 77 | 9 | Remdesivir, azithromycin, tocilizumab | Basiliximab, methylprednisolone, mycophenolate mofetil | Tacrolimus, mycophenolate mofetil, methylprednisolone | Alive |
*For all recipients, SARS-COV-2 test was by nasopharyngeal swab. COVID-19, coronavirus disease; HCW, healthcare worker; ICU, intensive care unit; SARS-COV-2, severe acute respiratory syndrome coronavirus 2. †If patient never discharged since organ transplantation, number of days hospitalized since organ transplantation. If patient discharged and re-admitted, number of days hospitalized since most recent admission. ‡For patients C, D, and F, day of death is considered last day of hospitalization, day in ICU, or day intubated.