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. 2021 Feb 2;10:e63284. doi: 10.7554/eLife.63284

Figure 1. Targeting Icmt improves survival and aorta and muscle phenotypes of progerin-knock-in mice.

Figure 1.

(a) Photograph of 15-week-old littermate female mice. (b) Kaplan-Meier plot showing survival of LmnaG609G/G609Icmthm/hm (n = 3) and LmnaG609G/G609GIcmthm/+ (n = 8) mice; the three double-homozygotes were killed for analyses when all the control mice had died of progeria. (c) Body weight curves of mice in panel B. (d) Number of vascular smooth muscle cell nuclei in medial layer of aortic arch sections. Data are mean of three mice/genotype. (e) Representative photographs of aortic arch sections from panel d. (f) Skeletal muscle fiber cross-sectional diameter. Data are mean of 50 independent muscle cells diameters in M. quadriceps extensor from three mice/genotype. (g) Kaplan-Meier plot showing survival of LmnaG609G/+Icmthm/hm (n = 5) and LmnaG609G/+Icmt+/+ (n = 14) mice. *p<0.05; **p<0.01; ***p<0.005; ****p<0.001; n.s., not significant.