Figure 2.

Overall Survival between Risk Groups Is Determined by Regulatory Leukocyte Abundance Postchemotherapy

(A) Percentage of monocytic myeloid-derived suppressor cells (mMDSCs) over total live cells. (B) Percentage of CD25hi, FOXP3⁺, Tregs over total number of CD3⁺ T cells. (C) Plasma concentration of CCL2. (D) Plasma concentration of CXCL10. (A–D) n = 34 (n = 7 high risk [blue dots and violin plot], 27 low risk [green dots and violin plot]). Significance calculated using Wilcoxon rank-sum test. (E) Transcriptome profile of PBMCs from postchemotherapy time point. Fold change (FC) was determined by comparison of the median gene expression between the high- and low-risk groups. p value was calculated using Welch’s t test without adjustment.