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. 2020 Sep 30;29(2):734–743. doi: 10.1016/j.ymthe.2020.09.040

Figure 3.

Figure 3

Overall Survival in Low-Risk Group Is Determined by an Increased Cytotoxic CD8 T Cell Signature

(A) Survival plot of low-risk individuals, stratified into short-term survivors (STSs) and long-term survivors (LTSs), as determined by the median survival of the low-risk group. Gehan-Breslow-Wilcoxon test, 95% CI shown between dashed lines. (B) Percentage of CD8+ T cells over total number of CD3+ T cells. (C) Percentage of CD8+ central memory T cells (CD45RA−, CCR7+) over total number of CD3+ T cells. (D) Percentage of CD8+ effector memory T cells (CD45RA−, CCR7−) over total number of CD3+ T cells. (E) Percentage of CD4+ T cells over total number of CD3+ T cells. (F) Plasma concentration of IFN-γ. (A–F) n = 27 (n = 14 STS [blue dots and violin plot], 13 LTS [green dots and violin plot]). Significance calculated using Wilcoxon rank-sum test. (G) Transcriptome profile of PBMCs from 2 weeks post-first immunotherapy time point. FC was determined by comparison of the median gene-expression between the STS and LTS groups. p value was calculated using Welch’s t test without adjustment.