Figure 6.

3xRx Significantly Increases the Penetrance of AAV-Induced HCC in Twi and WT Mice

(A) Representative images of gross normal liver (top panel) and HCC tumor (bottom panel) isolated from a terminal 3xRx-treated mouse. (B) The incidence of HCC (black fill) is increased in 3xRx-treated Twi (Twi 3xRx) and WT (WT 3xRx) mice compared to 2xRx-treated Twi mice (Twi 2xRx). (C) The level of the pro-apoptotic ceramide, 18:0, is significantly lower in tumor tissue (Twi 3xRx HCC) compared to normal-appearing liver tissue (Twi 3xRx Norm). The error bars represent one standard error of the mean, *p < 0.05.