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. 2020 Dec 3;29(2):645–657. doi: 10.1016/j.ymthe.2020.11.028

Figure 6.

Figure 6

Cell-Cell Interactions between CAR-T Subsets and Endogenous T Cells

(A) Heatmap showing the L-R pairs between CAR-T (highly proliferative and highly cytotoxic state) and endogenous T cells (clusters 8, 11, and 19). Rows represent the L-R pairs. Columns represent cell subset-cell subset pairs. The color gradient from purple to yellow indicates low to high mean values of the L-R pairs calculated by the CellPhoneDB tool. Only significant L-R pairs (p < 0.05) are colored. The colored names of L-R pairs correspond to the genes presented in (B). Bottom, L-R genes involved in GO terms. (B) Boxplot showing the selected ligand/receptor expression of in different clusters. (C) The schematic diagram indicates the relationship between CAR-T subsets and endogenous T cells at the peak phase.