Table 2.

Baseline-corrected pharmacokinetic parameters of N-acetylcysteine after single- (Days 1–2) and multiple-dose (Days 6–7) administration

	Days 1–2			Days 6–7
	Asian (n = 15)	Caucasian (n = 15)		Asian (n = 15)	Caucasian (n = 15)
Cmax, ng/mL	2711.7 ± 1270.3	2895.3 ± 842.4	Cmax,ss, ng/mL	3513.1 ± 1142.6	3419.3 ± 920.0
tmax, h	1.3 (0.5–3.0)	1.0 (0.8–1.5)	tmax,ss, h	1.0 (0.5–2.0)	1.0 (0.5–1.5)
AUC0-t, ng h/mL	10,657.5 ± 4108.7	10,614.0 ± 3114.5	AUC0-t,ss, ng h/mL	15,804.4 ± 4770.8	14,702.0 ± 3409.8
AUC0-12, ng h/mL	8792.1 ± 3353.0	8895.5 ± 2578.8	AUCτ,ss, ng h/mL	12,543.2 ± 3824.2	11,737.6 ± 2782.6
AUC0-∞, ng h/mL	11,691.8 ± 4623.6	12,031.1 ± 4119.0a	Cave,ss, ng/mL	1045.3 ± 318.7	978.1 ± 231.9
t½, h	15.4 ± 3.5	18.7 ± 7.2a	Cmin,ss, ng/mL	354.9 ± 109.6	306.9 ± 74.7
Vz, L	1250.0 ± 474.9	1400.8 ± 508.5a	PTF, %	303.6 ± 58.6	318.0 ± 38.8
CLt, L/h	56.9 ± 16.2	56.0 ± 20.1a	ARAUC	1.5 ± 0.4	1.4 ± 0.2

All data are presented as mean ± SD, except for t_max, which is presented as median (range)

AUC area under the curve, ARAUC accumulation ratio based on AUC, CL clearance, PTF peak-trough fluctuation, SD standard deviation

^an = 13