Table 2.
Days 1–2 | Days 6–7 | ||||
---|---|---|---|---|---|
Asian (n = 15) |
Caucasian (n = 15) |
Asian (n = 15) |
Caucasian (n = 15) |
||
Cmax, ng/mL | 2711.7 ± 1270.3 | 2895.3 ± 842.4 | Cmax,ss, ng/mL | 3513.1 ± 1142.6 | 3419.3 ± 920.0 |
tmax, h | 1.3 (0.5–3.0) | 1.0 (0.8–1.5) | tmax,ss, h | 1.0 (0.5–2.0) | 1.0 (0.5–1.5) |
AUC0-t, ng h/mL | 10,657.5 ± 4108.7 | 10,614.0 ± 3114.5 | AUC0-t,ss, ng h/mL | 15,804.4 ± 4770.8 | 14,702.0 ± 3409.8 |
AUC0-12, ng h/mL | 8792.1 ± 3353.0 | 8895.5 ± 2578.8 | AUCτ,ss, ng h/mL | 12,543.2 ± 3824.2 | 11,737.6 ± 2782.6 |
AUC0-∞, ng h/mL | 11,691.8 ± 4623.6 | 12,031.1 ± 4119.0a | Cave,ss, ng/mL | 1045.3 ± 318.7 | 978.1 ± 231.9 |
t½, h | 15.4 ± 3.5 | 18.7 ± 7.2a | Cmin,ss, ng/mL | 354.9 ± 109.6 | 306.9 ± 74.7 |
Vz, L | 1250.0 ± 474.9 | 1400.8 ± 508.5a | PTF, % | 303.6 ± 58.6 | 318.0 ± 38.8 |
CLt, L/h | 56.9 ± 16.2 | 56.0 ± 20.1a | ARAUC | 1.5 ± 0.4 | 1.4 ± 0.2 |
All data are presented as mean ± SD, except for tmax, which is presented as median (range)
AUC area under the curve, ARAUC accumulation ratio based on AUC, CL clearance, PTF peak-trough fluctuation, SD standard deviation
an = 13