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. 2020 Dec 13;30(2):285–298. doi: 10.1177/0961203320979045

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Illustration of the voxel-based association between WMH and: (a) measures of active disease (SLEDAI and anti-double-stranded DNA), (b) endothelial function indicators (von Willebrand factor antigen and homocysteine), (c) measures of clinical disease “damage” (SLICC + Lupus duration), and (d) vascular risk factors (smoker, hypertension (y/n), homocysteine, total cholesterol, anticardiolipin IgG and IgM). From left to right: representative coronal, sagittal and axial slices (above) and five axial slices (below) showing the brain voxels of the study template where positive (red) and negative (yellow) associations were found. The colour intensity is proportional to the strength of the association (normalised to absolute values between 0-maximum B-value for visual representation).