Skip to main content
. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Clin Cancer Res. 2020 Nov 10;27(3):799–806. doi: 10.1158/1078-0432.CCR-20-2861

Table 1.

Clinicopathologic features of patients with advanced MET exon 14-altered lung cancers.

Patients Treated with MET TKI (N = 75)
Age, median (range) 73 years (44-91 years)
Sex, % (N) Female 52% (39)
Cigarette smoking, % (N) Never
Former or Current
44% (33)
56% (42)
Histology, % (N) Adenocarcinoma
Sarcomatoid
Other
79% (59)
9% (7)
12% (9)
Number of MET TKIs, % (N) 1
2 or more
75% (56)
25% (19)
First MET TKI received, % (N) Crizotinib
Cabozantinib
Tepotinib
88% (66)
1% (1)
11% (8)
DNA-based NGS, % (N) MSK-IMPACT
Foundation One
95% (71)
5% (4)
MET Splice Site Region#, % (N) Intron 13 Acceptor
Intron 14 Donor
Fusion
Other
Not Detected by DNA-based NGS
33% (25)
60% (45)
3% (2)
3% (2)
1% (1)
MET Mutation Type#, % (N) Base substitution
Insertion/deletion
Large deletion (>35 bp)
Fusion
Other
Note Detected by DNA-based NGS
48% (36)
35% (26)
8% (6)
3% (2)
3% (2)
4% (3)

Percentages in select demographic groups do not add up to 100% due to rounding.