Table 1.
Patients Treated with MET TKI (N = 75) | ||
---|---|---|
Age, median (range) | 73 years (44-91 years) | |
Sex, % (N) | Female | 52% (39) |
Cigarette smoking, % (N) | Never Former or Current |
44% (33) 56% (42) |
Histology, % (N) | Adenocarcinoma Sarcomatoid Other |
79% (59) 9% (7) 12% (9) |
Number of MET TKIs, % (N) | 1 2 or more |
75% (56) 25% (19) |
First MET TKI received, % (N) | Crizotinib Cabozantinib Tepotinib |
88% (66) 1% (1) 11% (8) |
DNA-based NGS, % (N) | MSK-IMPACT Foundation One |
95% (71) 5% (4) |
MET Splice Site Region#, % (N) | Intron 13 Acceptor Intron 14 Donor Fusion Other Not Detected by DNA-based NGS |
33% (25) 60% (45) 3% (2) 3% (2) 1% (1) |
MET Mutation Type#, % (N) | Base substitution Insertion/deletion Large deletion (>35 bp) Fusion Other Note Detected by DNA-based NGS |
48% (36) 35% (26) 8% (6) 3% (2) 3% (2) 4% (3) |
Percentages in select demographic groups do not add up to 100% due to rounding.