Skip to main content
. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Mol Psychiatry. 2020 Dec 16;26(2):411–428. doi: 10.1038/s41380-020-00964-4

Figure 2. Akt2 genetically modified mice display impaired recency discrimination memory and object location memory, but intact novel object memory.

Figure 2.

(A–B) Temporal order recognition test of Akt2 HET and KO mice and their WT littermates. (A) Recency discrimination ratio of time spent exploring the more recent object compared to a less recent. The ratio is lower in HET (p = 0.002) and KO mice (p = 0.001). (B) Overall exploration time of both objects during samples 1, 2 and 3. N = 11 WT, 12 HET, 6 KO. (C–D) Novel object recognition test of Akt2 HET and KO mice and their WT littermates. (C) Preference index for time spent exploring the novel object compared to a familiar one. (D) Overall exploration time of the objects during samples 1 and 2. N = 10 WT, 11 HET, 6 KO. (E–F) Object location recognition of Akt2 HET and KO mice and their WT littermates. (E) Preference index for the time spent exploring the misplaced object compared to object in its original location. The index is significantly lower in KO mice (p = 0.049 KO vs WT). (F) Overall exploration time of the objects during samples 1 and 2. N = 10 WT, 10 HET, 5 KO. Data represent mean ± SEM. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.