Figure 6: CIRP^−/− mice have increased efferocytosis in sepsis.

(A, B) WT and CIRP^−/− mice were underwent sham and CLP operation. After 5 h of surgery all mice were injected with CFSE-labeled apoptotic cells (1 × 10⁷) via i.p. injection. After 1 h of injection of apoptotic cells, peritoneal washout cells were collected and stained with PE-F4/80 Ab and assessed efferocytosis by flow cytometry. Data were obtained from 3 independent experiments are expressed as means ± SE (n=6 mice/group). The groups were compared by one-way ANOVA and SNK method. *p<0.05 vs. relevant (WT or CIRP^−/−) sham mice; #p<0.05 vs. WT CLP mice.