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eCIRP is released during sepsis, which induces neutrophils to produce NETs. NE contained in the NETs cleaves αvβ3 and αvβ5 integrins expressed on the surface of macrophages. This leads to decreased binding of apoptotic cell’s opsonin MFG-E8 to the macrophage, thereby impairing the bridge formation between apoptotic cell and macrophage and inhibiting efferocytosis.
