Table 1 |.

Description of post-mortem cohort.

Cases used for snRNA-seq
Case #	Braak stage	Sex	Age at death (years)	Post-mortem interval (hours)	ADNC score	CDR before death	APOE genotype	Source
1	0	M	50	13	A0,B0,C0	0	E3/E3	BBAS
2	0	M	60	12	A0,B0,C0	0.5	E3/E3	BBAS
3	0	M	71	12	A1,B0,C0	0	E3/E3	BBAS
4	2	M	72	15	A1,B1,C0	0	E3/E3	BBAS
5*	2	M	77	4.9	A2,B1,C1	0.5	E3/E3	UCSF
6*	2	M	87	30	A2,B1,C2	2	E3/E3	UCSF
7*	2	M	91	50	A1,B1,C1	0	E3/E3	UCSF
8*	6	M	72	6.9	A3,B3,C3	3	E3/E3	UCSF
9*	6	M	82	6.7	A3,B3,C3	3	E3/E3	UCSF
10	6	M	82	9	A3,B3,C3	3	E3/E3	UCSF
Cases used for immunofluorescence validation
Case #	Braak stage	Sex	Age at death	Post-mortem interval (hours)	ADNC score	CDR before death	APOE genotype	Source
5*	2	M	77	4.9	A2,B1,C1	0.5	E3/E3	UCSF
6*	2	M	87	30	A2,B1,C2	2	E3/E3	UCSF
7*	2	M	91	50	A1,B1,C1	0	E3/E3	UCSF
8*	6	M	72	6.9	A3,B3,C3	3	E3/E3	UCSF
9*	6	M	82	6.7	A3,B3,C3	3	E3/E3	UCSF
11	0	F	62	10.1	A1,B0,C0	0	NA	BBAS
12	0	M	64	12	A0,B0,C0	0	E3/E3	BBAS
13	1	M	60	19	A0,B1,C0	0	NA	BBAS
14	1	F	64	13	A1,B1,C0	0	E3/E3	BBAS
15	1	M	70	11	A1,B1,C0	0	E3/E3	BBAS
16	1	F	82	9.6	A1,B1,C0	0	NA	BBAS
17	2	F	79	18	A1,B1,C1	0	E3/E3	BBAS
18	2	F	81	30.3	A1,B1,C0	NA	E3/E3	UCSF
19	3	M	81	8.3	A2,B2,C3	1	NA	UCSF
20	3	M	84	28	A3,B2,C2	1	NA	UCSF
21	3	F	88	9.8	A3,B2,C2	0.5	E3/E3	UCSF
22	3	M	89	9.1	A3,B2,C2	1	E3/E3	UCSF
23	4	F	87	9.5	A1,B2,C3	2	E3/E3	UCSF
24	4	M	91	11.2	A3,B2,C2	0.5	E3/E3	UCSF
25	4	M	103	7.8	A1,B2,C2	NA	E3/E3	UCSF
26	5	M	77	8.4	A3,B3,C3	0.5	E4/E4	UCSF
27	5	M	85	11.2	A3,B3,C3	1	E3/E3	UCSF
28	5	M	86	8.6	A3,B3,C3	2	E3/E4	UCSF
29	5	F	87	17	A3,B3,C2	3	E3/E3	BBAS
30	6	F	64	7.3	A3,B3,C3	3	E3/E4	UCSF
31	6	F	67	9.7	A3,B3,C3	3	E4/E4	UCSF

Asterisks denote cases used both for snRNA-seq and immunofluorescence validation. The AD neuropathological change (ADNC) score incorporates assessment of amyloid-beta deposits (“A”), staging of neurofibrillary tangles (“B”), and scoring of neuritic plaques (“C”)⁴⁸. The Clinical Dementia Rating (CDR) reflects the degree of cognitive impairment⁴⁹.