Table 3.
Immune cell populations in tumors grouped based on hypoxia risk scores.
| Immune cell population# | Comparison between hypoxia-high and hypoxia-low risk groups§ | |||||
|---|---|---|---|---|---|---|
| GB-High risk | HCC-High risk | LUAD-High risk | GB-Low risk | HCC-Low risk | LUAD-Low risk | |
| B cell naïve | – | P = 0.266 | P = 0.088 | – | P = 0.51 | |
| B cell memory | – | P = 0.468 | – | P < 0.001; P = 0.025 | ||
| Plasma cells | – | P = 0.411 | P = 0.515 | – | P = 0.323 | |
| T cells CD8 | – | P = 0.436 | – | P = 0.072 | P = 0.519 | |
| T cells CD4 naïve | – | – | P = 0.989; P = 0.38 | – | – | |
| T cells CD4 memory resting | P = 0.001; P = 0.001 | P = 0.082 | P < 0.001; P = 0.012 | |||
| T cells CD4 memory activated | – | P < 0.001; P < 0.001 | – | P = 0.226 | ||
| T cells follicular helpers | – | P = 0.606 | P = 0.857; P = 0.132 | – | ||
| T cells regulatory | P = 0.006; P < 0.001 | P = 0.077 | P = 0.265; P = 0.56 | |||
| T cells gamma delta | – | P = 0.727 | P = 0.384; P = 0.09 | – | ||
| NK cells resting | P = 0.009; P < 0.001 | P = 0.992 | P < 0.001; P < 0.001 | |||
| NK cells activated | – | P = 0.426; P = 0.672 | P < 0.001; P = 0.683 | P = 0.004 | ||
| Monocytes | – | P = 0.673 | – | P = 0.001; P = 0.001 | ||
| Macrophages M0 | P = 0.001; P = 0.03ǂ | P < 0.001 | P < 0.001; P < 0.001 | |||
| Macrophages M1 | P < 0.001; P = 0.02 | P = 0.011 | ||||
| Macrophages M2 | P = 0.526 | P = 0.845; P = 0.04 | ||||
| Dendritic cells resting | – | P = 0.856 | – | P < 0.001; P < 0.001 | ||
| Dendritic cells activated | – | P = 0.134 | P = 0.308 | – | P = 0.193 | |
| Mast cells resting | – | – | P < 0.002 | P < 0.001; P < 0.001 | ||
| Mast cells activated | – | P = 0.081 | P < 0.001; P = 0.013 | – | ||
| Eosinophils | – | P = 0.093 | P = 0.409 | – | P = 0.489 | |
| Neutrophils | P < 0.001; P = 0.001 | P = 0.002 | P = 0.035 | P = 0.167 | ||
#Expression of the immune cell populations was derived based on the analytical tools CIBERSORT (Cell-type Identification By Estimating Relative Subsets Of RNA Transcripts) (163–165).
§Hypoxia-high and hypoxia-low risk groups were compared in glioma (GB) (163), hepatocellular carcinoma (HC) (164) and lung adenocarcinoma (LUAD) datasets (165). P-values for the increasing immune populations in each group are presented. Two P-values are presented for GB and LUAD, which included two independent datasets. P-values < 0.05 were considered statistically significant and are presented in bold.
ǂIncrease was reported for tumor associated macrophages in total (163).
- data has not been reported in the paper.