Figure 2.

Anti-atherosclerotic role of miR-223-3p. MiR-223-3p plays important roles in atherosclerotic progression based on its effects on various types of cells involved in atherosclerosis including VECs, VSMCs, and macrophages. MiR-223-3p can suppress endothelial inflammation and activation through targeting ICAM1 and regulating NFκB and MAPK signaling pathways. MiR-223-3p also alleviates vascular remodeling mediated by proliferation and migration of VSMCs and lipid deposition and inflammation mediated by macrophages through PI3K/AKT or TLR4/NFκB signaling pathways. Besides, MiR-223-3p is an important endocrine signal factor for communication between platelets, monocytes, and vascular cells.