Table 1.
Verified target genes of miR-223-3p in CVDs.
| Gene | Gene function | Cell/Tissue type | Species | References |
|---|---|---|---|---|
| SR-BI | Cholesterol transport | Hepatocyte | Human | (32, 49) |
| VEC | (32) | |||
| HMGCS1* | Cholesterol biosynthesis | Hepatocyte | Human | (49) |
| SC4MOL* | Cholesterol biosynthesis | Hepatocyte | Human | (49) |
| Sp3* | Cholesterol efflux | Hepatocyte | Human | (49) |
| ICAM1* | Inflammation | VEC | Human | (46) |
| IGF1R | Proliferation, migration, apoptosis | VSMC | Rat, mouse | (35) |
| Proliferation, differentiation | PASMC | Human, rat, mouse | (169, 170) | |
| Hypertrophy | Cardiomyocyte | Rat, mouse | (137) | |
| NLRP3 | Inflammation, necroptosis | Cardiomycyte | Rat, mouse | (26) |
| Inflammation | Dendritic cell | Mouse | (178) | |
| IKKα* | Inflammation, necroptosis | Cardiomycyte | Rat, mouse | (26) |
| ITGB1 | Proliferation, migration | VEC | Human, mouse | (81) |
| Hypertrophy | Cardiomyocyte | Rat, mouse | (137) | |
| RPS6KB1* | Proliferation, migration | VEC | Rat | (37) |
| KLF15* | Hypoxia-induced apoptosis, oxidative stress | Cardiomycyte | Rat | (82) |
| RASA1* | Proliferation, migration, differentiation | Cardiac fibroblast | Rat | (85) |
| KCND2* | Electrophysiology | Cardiomyocyte | Rat | (94) |
| P2Y12 | Platelet aggregation, thrombus growth/stability | Platelet | Human | (103) |
| Megakaryocyte | ||||
| STIM1* | Hypertrophy | Cardiomyocyte | Rat | (125) |
| TNNI3K* | Hypertrophy | Cardiomyocyte | Rat | (124) |
| ARC* | Hypertrophy | Cardiomyocyte | Mouse | (33) |
| FBXW7* | Hypertrophy | Cardiomyocyte | Rat, mouse | (137) |
| ACVR2A* | Hypertrophy | Cardiomyocyte | Rat, mouse | (137) |
| ITGB3* | Proliferation, differentiation, DNA damage-induced apoptosis | PASMC | Rat | (169) |
| PARP1* | DNA damage-induced apoptosis | PASMC | Human, rat | (167, 169) |
| RHOB* | Proliferation, migration | PASMC | Human, rat | (168) |
| MYL2* | Proliferation, migration | PASMC | Human, rat | (168) |
| PKNOX1* | Activation, polarization | Macrophage | Mouse | (177) |
| STAT3 | Inflammation | Heart | Mouse | (27) |
| IL-6 | Inflammation | Heart | Mouse | (27) |
*
The target genes marked with an asterisk are cell-specific targets of miR-223-3p corresponding to the certain cell types in the table according to the current research.