Table 2.

Signaling pathways regulated by miR-223-3p in CVDs.

Signaling pathway	Cell function	Disease/Process	References
NFκB	Inflammation of VEC	Atherosclerosis	(54)
	Lipid accumulation and inflammation of macrophage	Atherosclerosis	(57)
	Inflammation and necroptosis of cardiomycyte	Myocardial I/R injury	(26)
TLR4	Lipid accumulation and inflammation of macrophage	Atherosclerosis	(57)
MAPK	Proliferation, migration, and inflammation of VEC	Atherosclerosis, cardiac angiogenesis	(37, 54)
	Proliferation, migration, and differentiation of cardiac fibroblast	Myocardial fibrosis following myocardial infarction	(85)
PI3K/AKT	Proliferation, migration, and apoptosis of VSMC	Atherosclerosis	(35)
	Inflammation of macrophage	Atherosclerosis	(57)
	Proliferation and migration of VEC	Cardiac angiogenesis	(37, 81)
	Hypertrophy of cardiomyocyte	Cardiac hypertrophy	(137)
	Proliferation, migration, and differentiation of cardiac fibroblast	Myocardial fibrosis following myocardial infarction	(85)
IGF1	Proliferation, migration, and apoptosis of VSMC	Atherosclerosis	(35)
	Hypertrophy of cardiomyocyte	Cardiac hypertrophy	(137)
	Proliferation and differentiation of PASMC	PAH	(169, 170)
NLRP3 inflammasome	Inflammation and necroptosis of cardiomycyte	Myocardial I/R injury	(26)
	Inflammation of dendritic cell	Autoimmune myocarditis	(178)
HIF-1α	Hypertrophy of cardiomyocyte	Cardiac hypertrophy	(137)
	Proliferation and migration of VEC	Cardiac angiogenesis	(37)
GF	Proliferation and migration of VEC	Cardiac angiogenesis	(37, 81)
BCL2 family-mediated apoptosis	Hypoxia-induced apoptosis of cardiomyocyte	Myocardial hypoxia	(82)
IL-6/STAT3	Inflammation of myocardium	Septic cardiomyopathy	(27)
RAS	Proliferation, migration, and differentiation of cardiac fibroblast	Myocardial fibrosis following myocardial infarction	(85)