Table 3.

Connectivity in DMN before (scan 1) and after (scan 2) cross-sex hormone treatment in TR persons, (no treatment in controls).

		Region	Cluster size (cc)	MAX	X	Y	Z
DMN	Between-group comparisons, scan 1
	Controls > TrW	mPFC	8.9	1.0	8	52	− 14
		lPFCa	3.7	1.0	− 48	16	32
			2.7	1.0	− 48	42	− 2
		BA 32 (ACC)	1.8	1.0	6	38	18
		L orbitofrontal cortex, BA 10 (PFC)	1.2	1.0	− 38	50	− 12
		BA 23 (PCC), precuneus	5.6	0.99	− 4	− 46	2
		L BA39 (angular gyrus)b	2.9	0.99	− 42	− 62	16
		L parietal cortex	1.8	0.99	− 26	− 72	44
		R parietal cortex	1.0	0.99	48	− 56	32
	Controls > TrM	R BA 32 (ACC)	7.9	1.0	10	32	16
		L BA 8 (dorsal medial prefrontal cortex	1.7	0.98	− 16	48	40
		L PFCa	2.2	0.99	− 54	40	− 4
		Precuneus	3.9	1.0	− 6	− 38	20
		L Ba39 (angular gyrus), superior parietal cortex	1.8	0.99	− 48	− 60	16
	Between-group comparisons, scan 2
		No significant clusters
	Within-group comparisons, scan 1 > scan 2 or the reverse
	Controls (scan 1 > scan 2)	R mPFC	2.1	0.99	6	58	− 8
	TrM (scan 2 > scan 1)	R PFCc	0.7	0.98	6	62	24
	TrW (scan 2 > scan 1)	R mPFCc	0.98	0.9	2	60	16
	Between-group comparison, scan 2 > scan 1
	TrW > controls	mPFC	1.1	0.99	16	52	16
					4	38	− 8
	TrM > controls	mPFC	8.5	1.0	6	54	0
		Precuneus	1.9	1.0	10	− 30	28

DMN, default mode network; mPFC, Mesial prefrontal cortex; lPFC, Lateral prefrontal cortex; ACC, Anterior cingulate cortex.

Calculations at 1 − p > 0.98, cluster size > 1.0 cc; Italics indicate sub-significant clusters (1 − p < 0.98, cluster size < 1.0 cc).

The CON < TrM and TrW clusters in anterior DMN could be partly constituted by lower connectivity in scan 2 vs 1 among controls, in addition to the increased connectivity in TrM and TrW in scan 2 vs 1. Scan 2 > 1 in the posterior DMN are constituted by scan 2 increases among the transgender group.

^aIncludes part of the dorsolateral prefrontal cortex.

^bIncludes superior parietal cortex.

^cIndicate sub-significant levels (cluster size < 1.0 cc), none of the other contrasts showed any clusters.