Table 3.
Bacterial genera exhibiting significant differential abundance (BH corrected p < 0.05) between the gut microbiomes of healthy controls (HC, n = 30) and type 2 diabetes mellitus (T2DM, n = 24) individuals.
| S. no. | Genus | Median abundance (%) | Characteristics | References | |
|---|---|---|---|---|---|
| HC | T2DM | ||||
| Genera decreased in T2DM | |||||
| 1 | Roseburia | 1.82 | 0.85 | aAnti-inflammatory | 65,66 |
| 2 | Lachnospira | 1.34 | 0.5 | aAnti-inflammatory | 65 |
| 3 | Sutterella | 0.52 | 0.14 | Pro-inflammatory | 67 |
| 4 | Coprococcus | 0.37 | 0.21 | aAnti-inflammatory | 65,66 |
| 5 | Phascolarctobacterium | 0.23 | 0.02 | aAnti-inflammatory | 68,69 |
| 6 | Haemophilus | 0.17 | 0.06 | Pathogen | 70 |
| 7 | Blautia | 0.15 | 0.08 | aAnti-inflammatory/antibacterial | 65,69,71,72 |
| 8 | Comamonas | 0.01 | 0 | Pathogen | 73 |
| 9 | Anaerostipes | 0.01 | 0 | aAnti-inflammatory | 66,71 |
| 10 | Turicibacter | 0.01 | 0 | Not known | |
| Genera increased in T2DM | |||||
| 1 | Acidaminococcus | 0.09 | 0.21 | aAnti-inflammatory | 65,68 |
| 2 | Escherichia | 0.04 | 0.13 | Pathogen | 74 |
| 3 | Lachnobacterium | 0.04 | 0.09 | Not known | |
| 4 | Butyricimonas | 0.01 | 0.09 | aAnti-inflammatory | 65 |
| 5 | Enterobacter | 0.01 | 0.07 | Pathogen | 74 |
| 6 | Methanobrevibacter | 0.01 | 0.05 | Pro-inflammatory | 75 |
| 7 | Treponema | 0 | 0.03 | Pathogen | 76 |
| 8 | Weissella | 0 | 0.01 | Probiotic/anti-inflammatory/antibacterial | 77,78 |
aBased on the capability to produce short chain fatty acid.