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. 2021 Feb 2;7:27. doi: 10.1038/s41420-020-00382-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Bioinformatics predictive tools (TargetScan, miRDB, PicTar) identified multiple proteins that could be targeted by LINC00958/miR-378a-3p. B Luciferase reporter vectors for YY1 mRNA (wild type and mutant) were synthesized. C Luciferase gene reporter assay found that miR-378a-3p mimics/control connected with the YY1 mRNA wild type/mutant. D RT-PCR analysis found YY1 mRNA in MCF-7 cells transfected with miR-378a-3p mimics/inhibitor or LINC00958 knockdown/overexpression. E T-PCR analysis showed YY1 mRNA expression in MCF-7 cells and normal cells (MCF-10A). F Correlation analysis using Pearson’s χ² method indicated the correlation with YY1 and LINC00958/miR-378a-3p. **p < 0.01 and *p < 0.05 were considered significant.