Table 2.

Hemodynamic variable before and after decreasing norepinephrine dose.

Variable	MAP Responder N = 12	MAP Non-responder N = 27	p
Norepinephrine dose (ug/kg/min)
Before	0.18 [0.10;0.21]	0.21 [0.09;0.42]	0.63
After	0.13 [0.06;0.17]*	0.14 [0.05;0.37]*	0.82
Heart rate (BPM)
Before	85 (21)	99 (19)	0.05
After	85 (20)	98 (18)	< 0.05
Stroke volume (mL)
Before	53 (19)	52 (16)	0.72
After	53 (19)	52 (16)	0.82
Cardiac output (mL/min)
Before	4.6 (2.2)	5.1 (1.8)	0.48
After	4.6 (2.2)	5.1 (1.9)	0.47
Systolic arterial pressure (mmHg)
Before	123 [111;128]	119 [109;127]	0.64
After	96 [94;106]*	114 [107;122]*	< 0.01
Diastolic arterial pressure (mmHg)
Before	57 (9)	59 (9)	0.46
After	50 (5)*	57 (8)*	< 0.01
Mean arterial pressure (mmHg)
Before	78 (8)	79 (9)	0.61
After	66 (6)*	77 (8)*	< 0.01
Central venous pressure (mmHg)
Before	12 [11;13]	11 [7;14]	0.93
After	11 [10;12]	11 [7;13]*	0.88
Dynamic elastance (echography)
Before	0.40 [0.24;0.57]	0.95 [0.77;1.09]	< 0.01
After	0.31 [0.26;0.71]	0.76 [0.55;1.09]	0.03
Stroke volume variation (echography)
Before	25 [15;37]	13 [9;19]	0.02
After	22 [14;29]	15 [9;24]	0.13
Pulse pressure variation
Before	8 [5;16]	12 [8;16]	0.30
After	9 [6;15]	13 [8;17]	0.39

p value refer to between group comparison, * represent significant differences for within group (before-after) comparison.

MAP: mean arterial pressure.