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. 2021 Feb 2;11:2784. doi: 10.1038/s41598-021-82431-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A combination of EZH2 and AMPK inhibitor synergize to reduce sphere-forming capability and induces cell death. (a) Cancer cells HeLa, HCT116, and 22Rυ1 were grown in low attachment plates, and E.C.M. detached cells were treated with different concentrations of GSK343 and Compound C for 2–8 days, and images were captured by Nikon inverted light microscope at ×40. Images were analyzed for size measurement using image J software (mean ± S.E.M., n = 8). A total number of 100 spheroids were quantified for size analysis; *P < 0.05. (b) Cancer cells HeLa, HCT116, and 22Rυ1 were grown in low attachment plates, and E.C.M. detached cells were treated with different concentrations of GSK343 and Compound C for 8 days, and apoptosis was quantified by using Annexin V/PI staining.