Fig. 1. Overall structure of Y₂R–JNJ-31020028 complex.

a Side view of the Y₂R–JNJ-31020028 structure. Y₂R is shown in light blue cartoon representation. JNJ-31020028 (carbon in yellow, nitrogen in blue, oxygen in red, fluorine in cyan) is shown in sphere representation. The disulfide bond is shown as orange sticks. b, c Structural comparison of Y₂R with inactive Y₁R (PDB code: 5ZBQ) and active NTSR1 (PDB code: 6OS9). The helical bundles of Y₂R, Y₁R, and NTSR1 are colored light blue, light cyan, and pink, respectively. JNJ-31020028 is shown as sticks. b Extracellular view. Red arrows indicate the movements of helices II and VI in the Y₂R structure compared to the structures of Y₁R and NTSR1. c Intracellular view. Red arrow indicates the conformational change of helix VI in the active NTSR1 structure relative to the structures of Y₁R and Y₂R.