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. 2021 Feb 2;7:8. doi: 10.1038/s41421-020-00238-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Heatmap of differential expression of cell surface proteins in Pre- and Post-EPIs in pig, human, and monkey. b Scatter-plot of genes encoding species-specific surface proteins. P-Pre, pig ICM and Pre- EPIs; P-Post, pig PostE- and PostL- EPIs; H-Pre, human D6-EPIs; H-Post, human D8- and D10-EPIs; M-Pre, monkey ICM and Pre-EPIs; M-Post, monkey PostE- and PostL-EPIs. Using Pre-EPIs as a control, fold change of gene expression in each cell relative to the average expression level in Pre-EPIs was calculated. c Overlaps of the interaction relationship between PostL-EPIs and PostL-TEs in each species. d Box plot showing the expression of top 5 claudin genes in Pre- and Post- EPIs in each species. Stage information was indicated as follows: Pre-, Day 5 or/and Day 7, PreE-, Day 5; PreL-, Day 7; Post-, Day 10 and Day 12; PostE-, Day 10; PostL-, Day 12. The horizontal lines in b indicate the mean values. To avoid the influence caused by the “0” value, a new matrix was generated by using FPKM + 1 and the log₂-transformed fold change was calculated.