Table 1.
Hazard Ratios (HR), 95% Confidence Intervals (CI), and P-values for first-time glaucoma drainage device (GDD) failures and complications as well as second-time GDD failures in pediatric eyes
| First-Time GDD Failure | First-Time GDD Complications | Second-Time GDD Failure | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Groups Compared | Hazard Ratio | HR 95% CI | Hazard Ratio | HR 95% CI | Hazard Ratio | HR 95% CI | ||||||
| low | high | p - value | low | high | p - value | low | high | p - value | |||||
| Categorical Variables | HR is for a change from the first category to the second category | ||||||||||||
| Concurrent Procedure | NONE to Glaucoma-Related Surgery ± Anterior Segment Surgery | 1.2 | 0.18 | 7.5 | 0.88 | 0.50 | 0.066 | 3.7 | 0.50 | 13 | 1.9 | 93 | 0.0085** |
| Type of Glaucoma | Glaucoma associated with acquired condition vs. Glaucoma associated with non-acquired systemic disease or syndrome | 12 | 2.0 | 74 | 0.0063** | 0.71 | 0.18 | 2.9 | 0.63 | No Failures with diagnosis Glaucoma associated with acquired condition | |||
| Glaucoma associated with acquiredcondition vs. Glaucoma associated with non-acquired ocular anomalies | 12 | 2.0 | 68 | 0.0054** | 1.4 | 0.46 | 4.1 | 0.58 | No Failures with diagnosis Glaucoma associated with acquired condition | ||||
| Glaucoma associated with acquired condition vs. Primary Congenital Glaucoma | 5.4 | 1.1 | 27 | 0.041** | 1.2 | 0.43 | 3.2 | 0.77 | No Failures with diagnosis Glaucoma associated with acquired condition | ||||
| Type of Implant | Ahmed to Baerveldt | 0.82 | 0.33 | 2.0 | 0.66 | 1.4 | 0.62 | 3.4 | 0.40 | 1.6 | 0.13 | 20 | 0.72 |
| Age Less than 1 Year Old | Older to Younger Age | 1.6 | 0.67 | 3.8 | 0.29 | 1.7 | 0.89 | 3.3 | 0.10 | 27 | 2.7 | 27 × 10^1 | 0.0053** |
| Age Less than 2 Years Old | Older to Younger Age | 2.2 | 0.89 | 5.3 | 0.088 | 1.9 | 1.0 | 3.7 | 0.046** | 1.7 | 0.27 | 10 | 0.58 |
| Age Less than 3 Years Old | Older to Younger Age | 2.0 | 1.0 | 4.9 | 0.14 | 2.1 | 1.1 | 4.0 | 0.024** | 0.98 | 0.22 | 4.4 | 0.98 |
| Continuous Variables | Hazard Ratio is for this many units increase | ||||||||||||
| Age at Surgery | Unit = 3 Years | 0.77 | 0.61 | 0.98 | 0.034** | 0.87 | 0.73 | 1.0 | 0.14 | 0.94 | 0.61 | 1.5 | 0.78 |
| Pre-Operative IOP | Unit = 5 mmHg | 1.2 | 0.97 | 1.5 | 0.086 | 1.2 | 1.0 | 1.5 | 0.038** | 0.68 | 0.39 | 1.2 | 0.17 |
| Pre-Operative Number of Glaucoma Medications | Unit = 1 medication | 0.74 | 0.51 | 1.1 | 0.11 | 1.0 | 0.72 | 1.5 | 0.87 | 0.89 | 0.53 | 1.5 | 0.67 |
(**)
A p-value < 0.05 was considered statistically significant
The single Molteno tube in the study was removed from analyses comparing Ahmed to Baerveldt, but included elsewhere.