Table 2.
Bioinformatic analysis of key networks, functions, and pathways regulated by the top 60 miRNAs. Ingenuity Pathway Analysis (IPA) was used to analyze the pathways and cellular functions predicted to be altered by experimentally validated targets of the top 60 miRNAs. Score is defined as −log10(p-value).
| Top Networks | ||||||
|---|---|---|---|---|---|---|
| Associated Network Functions | Score | |||||
| Cell Death and Survival, Cancer, Cell Cycle | 39 | |||||
| Cell Signaling, Cardiovascular Disease, Dermatological Diseases and Conditions | 12 | |||||
| Cell Death and Survival, Cellular Development, Cellular Growth and Proliferation | 4 | |||||
| Top Tox Functions | ||||||
|---|---|---|---|---|---|---|
| Molecular and cellular functions | p-value | #Molecules | ||||
| Cellular Movement | 6.54E-05 – 9.58E-18 | 21 | ||||
| Cell Death and Survival | 6.95E-05 – 1.41E-17 | 21 | ||||
| Cellular Development | 6.23E-05 – 2.26E-16 | 22 | ||||
| Cellular Growth and Proliferation | 6.95E-05 – 2.26E-16 | 21 | ||||
| Cell Morphology | 6.95E-05 – 6.37E-15 | 17 | ||||
| Top Canonical Pathways | |||||
|---|---|---|---|---|---|
| Molecular and cellular functions | p-value | % Overlap, #Molecules | |||
| Cancer Drug Resistance by Drug Efflux | 4.59E-69 | 51.0%, 25/49 | |||
| PI3K/AKT Signaling | 8.68E-41 | 16.3%, 20/123 | |||
| Prostate Cancer Signaling | 2.54E-40 | 20.0%, 19/95 | |||
| Melanoma Signaling | 2.67E-39 | 30.9%, 17/55 | |||
| PTEN Signaling | 2.75E-38 | 16.0%. 19/199 | |||
Overlap percentage is generated from the number of genes targeted relative to the number of genes involved in the canonical pathways (indicated on the right).