Table 1.
pDCs Markers in Humans and Mice
| Marker | Human | Mouse |
|---|---|---|
| CD1a (Langerhans cell marker) | − (Facchetti et al. 1988) (Grouard et al. 1997) (Olweus et al. 1997) |
N/A |
| CD3 (T cell marker; T cell co-receptor) | − (Muller-Hermelink et al. 1983) (Harris et al. 1987) (Horny et al. 1987) (Facchetti et al. 1988) (Grouard et al. 1997) (Olweus et al. 1997) (Bendriss-Vermare et al. 2001) |
− (Asselin-Paturel et al. 2003) |
| CD4 (T cell co-receptor) | + (Muller-Hermelink et al. 1983) (Harris et al. 1987) (Horny et al. 1987) (Facchetti et al. 1988) (Grouard et al. 1997) (Olweus et al. 1997) (Bendriss-Vermare et al. 2001) |
+ (Nakano et al. 2001) (Martin et al. 2002) (Omatsu et al. 2005) |
| CD8 (T cell co-receptor) | − (Muller-Hermelink et al. 1983) (Harris et al. 1987) (Horny et al. 1987) (Facchetti et al. 1988) (Grouard et al. 1997) (Bendriss-Vermare et al. 2001) |
+/− (Asselin-Paturel et al. 2001) (Nakano et al. 2001) (Martin et al. 2002) (Asselin-Paturel et al. 2003) low (Castellaneta et al. 2004) (Omatsu et al. 2005) |
| CD11b (αM integrin; usually non-covalently associates with β2 integrin [CD18]) | − (Harris et al. 1987) (Facchetti et al. 1988) (Grouard et al. 1997) (Olweus et al. 1997) (Bendriss-Vermare et al. 2001) |
− (Nakano et al. 2001) (Martin et al. 2002) (Asselin-Paturel et al. 2003) (Castellaneta et al. 2004) |
| CD11c (αx integrin; usually forms a heterodimer with β2 integrin [CD18]) | − (Facchetti et al. 1988) (Grouard et al. 1997) (Olweus et al. 1997) |
+/++ (Nakano et al. 2001) (Asselin-Paturel et al. 2003) (Castellaneta et al. 2004) (Omatsu et al. 2005) (Contractor et al. 2007) and NK cells: (Blasius et al. 2007) |
| CD14 (LPS receptor; mainly expressed by monocytes and macrophages) | − (Facchetti et al. 1988) (Grouard et al. 1997) (Olweus et al. 1997) (Bendriss-Vermare et al. 2001) |
|
| CD16 (low affinity IgG receptor, mainly expressed by NK cells, activated monocytes, and macrophages) | − (Grouard et al. 1997) (Olweus et al. 1997) |
|
| CD19 (member of the Ig superfamily, expressed on all stages of B cell development from pro-B cells to mature B cells) | − (Grouard et al. 1997) (Olweus et al. 1997) |
− (Nakano et al. 2001) (Martin et al. 2002) (Asselin-Paturel et al. 2003) (Contractor et al. 2007) |
| CD45R/B220 (an isoform of CD45, expressed at all developmental stages of B cells, from pro-B cells through mature B cells) | + (Nakano et al. 2001) (Asselin-Paturel et al. 2003) (Castellaneta et al. 2004) (Omatsu et al. 2005) (Contractor et al. 2007) And NK cells: (Blasius et al. 2007) NK cell progenitors: (Rolink et al. 1996) |
|
| CD123 (IL3Ra) | ++ (Olweus et al. 1997) (Bendriss-Vermare et al. 2001) also present on blood monocytes: (Buelens et al. 2002) cDCs: (Masten et al. 2006) cDC precursors: (Breton et al. 2016), (See et al. 2017) |
− (As IL-3Ra) (Martin et al. 2002) − (Asselin-Paturel et al. 2001) Low (Bjorck 2001) Low: (O’Keeffe et al. 2002) |
| CD56 (A single transmembrane glycoprotein member of the Ig superfamily, mainly expressed by NK and NKT cells) | − (Grouard et al. 1997) (Olweus et al. 1997) (Bendriss-Vermare et al. 2001) |
|
| CD303 (BDCA-2; a type II transmembrane glycoprotein member of the C-type lectin superfamily) | +* (Dzionek et al. 2000) |
N/A |
| CD304 (BDCA-4; a type I transmembrane protein implicated in a variety of biologic functions; VEGF165/semaphorin-3A receptor) | (Dzionek et al. 2000) | N/A |
| ILT3 (a type I membrane protein expressed by DCs and monocytes) | + And monocytes, macrophages, and cDCs: (Cella et al. 1997) (Cao et al. 2006) |
|
| ILT7 (a member of leukocyte immunoglobulin-like receptor family) | +* (Cao et al. 2006) |
|
| Gr-1 (Ly6C/Ly6G) | + (Nakano et al. 2001) low (Asselin-Paturel et al. 2003) low (Castellaneta et al. 2004) (Contractor et al. 2007) |
|
| Ly6C (a member of the Ly6 family of GPI linked protein, expressed by various murine immune cells) | N/A | + (Asselin-Paturel et al. 2003) (Omatsu et al. 2005) |
| Ly6G (a member of the Ly6 family of GPI linked protein, expressed on the majority of myeloid cells and granulocytes) | − (Asselin-Paturel et al. 2003) |
|
| Ly49Q (a type II C-type lectin membrane-associated polypeptide) | + (Omatsu et al. 2005) |
|
| PDCA-1 (Bst-2; a type II transmembrane glycoprotein, an IFN-induced response factor) | + Also tumor cells: (Walter-Yohrling et al. 2003) |
+ (Asselin-Paturel et al. 2003) (Blasius et al. 2006) (Contractor et al. 2007) Also other cells: (Blasius et al. 2006) |
| Siglec-H (a member of CD33-related Siglec family) | N/A | + |
| CD45 (a single chain type I membrane glycoprotein; expressed by all immune cells) | + (Facchetti et al. 1988) |
+ |
−: negative; +: present; ++:high levels
*:
considered pDC specific
N/A: Not applicable
ILT: immunoglobulin-like transcript
BDCA: blood dendritic cell antigen
PDCA-1: plasmacytoid dendritic cell antigen-1
Bst-2: Bone marrow stromal antigen-2