Table 2.

Association of baseline (i.e. pre-treatment) type 2 diabetes with mortality and liver-related outcomes by SVR (YES/NO) and presence of baseline cirrhosis (YES/NO)

	Mortality			HCC			Cirrhosis			Decompensated cirrhosis
	HR	Adj. HR*	Adj. HR†	HR	Adj. HR*	Adj. HR†	HR	Adj. HR*	Adj. HR†	HR		Adj. HR*	Adj. HR†
PATIENTS WITH SVR
No Diabetes	1	1	1	1	1	1	1	1	1		1	1	1
Diabetes	1.49 (1.37–1.61)	1.14 (1.04–1.25)	1.15 (1.05–1.26)	1.39 (1.21–1.59)	1.07 (0.92–1.25)	1.09 (0.93–1.28)	1.54 (1.38–1.73)	1.36 (1.19–1.55)	1.32 (1.16–1.51)		1.74 (1.55–1.96)	1.21 (1.06–1.38)	1.21 (1.05–1.38)
PATIENTS WITH NO SVR
No Diabetes	1	1	1	1	1	1	1	1	1		1	1	1
Diabetes	1.27 (1.10–1.48)	1.16 (0.98–1.37)	1.20 (1.01–1.42)	1.37 (1.13–1.66)	1.18 (0.95–1.47)	1.24 (0.99–1.56)	1.50 (1.19–1.89)	1.28 (0.96–1.71)	1.20 (0.90–1.61)		1.22 (1.00–1.48)	0.99 (0.80–1.24)	0.99 (0.79–1.23)
PATIENTS WITH CIRRHOSIS
No Diabetes	1	1	1	1	1	1	N/A	N/A	N/A		1	1	1
Diabetes	1.15 (1.04–1.26)	1.09 (0.98–1.21)	1.10 (0.99–1.22)	1.05 (0.92–1.20)	1.04 (0.90–1.20)	1.06 (0.92–1.23)	N/A	N/A	N/A		1.09 (0.97–1.22)	1.04 (0.92–1.18)	1.04 (0.92–1.18)
PATIENT WITHOUT CIRRHOSIS
No Diabetes	1	1	1	1	1	1	1	1	1		1	1	1
Diabetes	1.54 (1.39–1.71)	1.20 (1.06–1.36)	1.25 (1.10–1.42)	1.40 (1.12–1.75)	1.23 (0.94–1.60)	1.32 (1.01–1.72)	1.55 (1.40–1.71)	1.35 (1.20–1.52)	1.31 (1.16–1.48)		2.09 (1.67–2.62)	1.79 (1.36–2.35)	1.74 (1.31–2.31)

HR: Hazard ratio, Adj. HR: Adjusted Hazard Ratio

^*Adjusted for SVR, history of cirrhosis or decompensated cirrhosis or HCC, age, sex, race/ethnicity, HCV genotype, HIV co-infection, HBV co-infection, Charlson Comorbidity Index, platelet count, serum bilirubin, serum creatinine, serum albumin, serum AST/√ALT ratio, blood INR, blood hemoglobin levels

^†Adjusted for obesity and diabetes as well as all the characteristics listed above