Table 3.
Association of baseline (i.e. pre-treatment) BMI categories with mortality and liver-related outcomes by SVR (YES/NO) and presence of baseline cirrhosis (YES/NO)
| Mortality | HCC | Cirrhosis | Decompensated cirrhosis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | Adj. HR* | Adj. HR† | HR | Adj. HR* | Adj. HR† | HR | Adj. HR* | Adj. HR† | HR | Adj. HR* | Adj. HR† | ||
| PATIENTS WITH SVR | |||||||||||||
| Underweight <18.5 | 1.72 (1.34–2.22) | 1.59 (1.20–2.10) | 1.62 (1.22–2.14) | 0.64 (0.32–1.30) | 0.66 (0.29–1.48) | 0.66 (0.29–1.50) | 0.83 (0.50–1.37) | 0.73 (0.41–1.30) | 0.76 (0.43–1.36) | 0.50 (0.23–1.05) | 0.71 (0.33–1.51) | 0.74 (0.35–1.57) | |
| Normal Weight 18.5 to<25 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Overweight 25 to <30 | 0.80 (0.73–0.88) | 0.82 (0.74–0.91) | 0.81 (0.73–0.90) | 0.87 (0.74–1.04) | 0.75 (0.63–0.90) | 0.75 (0.62–0.89) | 1.13 (0.98–1.30) | 1.15 (0.99–1.34) | 1.13 (0.97–1.31) | 1.05 (0.89–1.22) | 1.03 (0.87–1.21) | 1.01 (0.86–1.20) | |
| Obese I 30 to <35 | 0.90 (0.81–1.01) | 0.90 (0.80–1.01) | 0.88 (0.78–0.99) | 1.00 (0.83–1.21) | 0.85 (0.70–1.03) | 0.84 (0.69–1.02) | 1.18 (1.01–1.38) | 1.18 (0.99–1.40) | 1.13 (0.95–1.34) | 1.13 (0.95–1.35) | 1.00 (0.83–1.20) | 0.97 (0.81–1.17) | |
| Obese II & III >35 | 1.14 (1.00–1.29) | 1.04 (0.91–1.19) | 1.01 (0.88–1.15) | 1.00 (0.79–1.26) | 0.77 (0.60–0.98) | 0.75 (0.59–0.96) | 1.41 (1.17–1.71) | 1.28 (1.04–1.57) | 1.19 (0.97–1.46) | 1.48 (1.22–1.81) | 1.07 (0.87–1.32) | 1.02 (0.83–1.26) | |
| PATIENTS WITH NO SVR | |||||||||||||
| Underweight <18.5 | 0.89 (0.44–1.81) | 0.94 (0.46–1.93) | 0.94 (0.46–1.94) | 0.85 (0.31–2.31) | 0.96 (0.35–2.63) | 0.92 (0.33–2.54) | 1.33 (0.48–3.64) | 2.10 (0.74–5.94) | 2.14 (0.76–6.06) | 0.99 (0.36–2.69) | 0.92 (0.33–2.54) | 0.92 (0.33–2.55) | |
| Normal Weight 18.5 to<25 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Overweight 25 to <30 | 0.86 (0.72–1.04) | 0.83 (0.68–1.01) | 0.81 (0.66–1.00) | 1.14 (0.89–1.46) | 0.93 (0.72–1.22) | 0.91 (0.69–1.19) | 1.39 (1.02–1.90) | 1.26 (0.90–1.76) | 1.25 (0.89–1.74) | 1.14 (0.87–1.48) | 0.94 (0.71–1.26) | 0.95 (0.71–1.26) | |
| Obese I 30 to <35 | 0.82 (0.67–1.00) | 0.80 (0.64–0.99) | 0.77 (0.62–0.96) | 0.92 (0.70–1.21) | 0.73 (0.54–0.98) | 0.70 (0.52–0.95) | 1.58 (1.14–2.19) | 1.55 (1.10–2.19) | 1.51 (1.06–2.13) | 1.17 (0.89–1.55) | 0.90 (0.66–1.22) | 0.90 (0.66–1.22) | |
| Obese II & III >35 | 0.80 (0.63–1.01) | 0.74 (0.57–0.96) | 0.71 (0.55–0.93) | 0.97 (0.71–1.33) | 0.71 (0.50–1.00) | 0.67 (0.47–0.95) | 1.81 (1.25–2.62) | 1.58 (1.06–2.35) | 1.51 (1.01–2.27) | 1.65 (1.23–2.22) | 1.15 (0.83–1.58) | 1.15 (0.83–1.59) | |
| PATIENTS WITH CIRRHOSIS | |||||||||||||
| Underweight <18.5 | 1.08 (0.68–1.71) | 1.04 (0.65–1.68) | 1.05 (0.65–1.69) | 0.75 (0.35–1.60) | 0.62 (0.26–1.52) | 0.62 (0.26–1.52) | N/A | N/A | N/A | 0.53 (0.23–1.18) | 0.58 (0.26–1.32) | 0.59 (0.261.32) | |
| Normal Weight 18.5 to<25 | 1 | 1 | 1 | 1 | 1 | 1 | N/A | N/A | N/A | 1 | 1 | 1 | |
| Overweight 25 to <30 | 0.77 (0.68–0.87) | 0.80 (0.70–0.91) | 0.79 (0.70–0.91) | 0.90 (0.76–1.06) | 0.84 (0.70–1.00) | 0.83 (0.70–0.99) | N/A | N/A | N/A | 0.95 (0.82–1.10) | 0.96 (0.82–1.13) | 0.96 (0.82–1.12) | |
| Obese I 30 to <35 | 0.83 (0.72–0.95) | 0.86 (0.75–0.99) | 0.85 (0.74–0.98) | 0.96 (0.80–1.15) | 0.87 (0.71–1.05) | 0.86 (0.71–1.04) | N/A | N/A | N/A | 0.97 (0.82–1.14) | 0.93 (0.78–1.11) | 0.93 (0.78–1.11) | |
| Obese II & III >35 | 0.97 (0.84–1.13) | 0.98 (0.83–1.15) | 0.96 (0.82–1.13) | 0.87 (0.70–1.09) | 0.73 (0.58–0.92) | 0.72 (0.57–0.91) | N/A | N/A | N/A | 1.17 (0.97–1.40) | 1.01 (0.83–1.22) | 1.00 (0.82–1.21) | |
| PATIENT WITHOUT CIRRHOSIS | |||||||||||||
| Underweight <18.5 | 2.02 (1.52–2.68) | 1.71 (1.25–2.35) | 1.76 (1.29–2.41) | 0.78 (0.32–1.91) | 0.89 (0.36–2.19) | 0.92 (0.37–2.27) | 0.87 (0.56–1.37) | 0.87 (0.53–1.44) | 0.90 (0.55–1.49) | 1.28 (0.52–3.19) | 1.32 (0.52–3.31) | 1.43 (0.57–3.58) | |
| Normal Weight 18.5 to<25 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Overweight 25 to <30 | 0.79 (0.70–0.90) | 0.85(0.74–0.97) | 0.83 (0.73–0.95) | 0.78 (0.61–1.01) | 0.73 (0.55–0.95) | 0.71 (0.54–0.94) | 1.15 (1.01–1.30) | 1.16 (1.01–1.33) | 1.14 (0.99–1.30) | 1.11 (0.82–1.50) | 1.17 (0.85–1.63) | 1.12 (0.81–1.56) | |
| Obese I 30 to <35 | 0.86 (0.75–0.99) | 0.91 (0.78–1.06) | 0.87 (0.75–1.01) | 0.65 (0.48–0.89) | 0.66 (0.47–0.91) | 0.63 (0.45–0.87) | 1.24 (1.08–1.43) | 1.23 (1.06–1.43) | 1.18 (1.01–1.38) | 1.15 (0.81–1.61) | 1.11 (0.76–1.61) | 1.00 (0.68–1.46) | |
| Obese II & III >35 | 1.01 (0.86–1.20) | 0.94 (0.78–1.13) | 0.88 (0.73–1.07) | 0.83 (0.57–1.21) | 0.73 (0.49–1.08) | 0.68 (0.46–1.02) | 1.50 (1.27–1.77) | 1.31 (1.10–1.57) | 1.23 (1.02–1.47) | 1.99 (1.38–2.85) | 1.58 (1.06–2.36) | 1.36 (0.90–2.04) | |
HR: Hazard Ratio, Adj. HR: Adjusted Hazard Ratio
*
Adjusted for SVR, history of cirrhosis or decompensated cirrhosis or HCC, age, sex, race/ethnicity, HCV genotype, HIV co-infection, HBV co-infection, Charlson Comorbidity Index, platelet count, serum bilirubin, serum creatinine, serum albumin, serum AST/√ALT ratio, blood INR, blood hemoglobin levels
†
Adjusted for obesity and diabetes as well as all the characteristics listed above.