Table 2.

Genetic testing results, by colorectal adenoma count and ancestry

Colorectal adenoma count, No.	Ashkenazi n (%)	Other Ancestry	Odds Ratio (95% CI)*	P value
		n (%)
1–19	115 (100)	2123 (100)
Pathogenic APC	3 (3)	99 (5)	0.57 (0.11–1.80)	0.50
Biallelic MUTYH	0 (0)	58 (3)	0.23 (0–1.02)	0.11
Monoallelic MUTYH	1 (0.9)	39 (2)	0.47 (0.01–2.81)	0.76
APC p.I1307K	19 (17)	14 (0.7)	27.43 (12.48–61.53)	<0.0001
No APC or MUTYH variants	74 (64)	1752 (83)	0.38 (0.25–0.58)	<0.001
20–99	131 (100)	3289 (100)
Pathogenic APC	14 (11)	339 (10)	1.30 (0.65–2.43)	0.48
Biallelic MUTYH	1 (1)	243 (7)	0.11 (0.003–0.61)	<0.01
Monoallelic MUTYH	1 (0.8)	77 (2)	0.23 (0- ∞)	0.11
APC p.I1307K	16 (12)	13 (0.4)	34.61 (14.87 – 82.69)	<0.0001
No APC or MUTYH variants	82 (63)	2369 (72)	0.57 (0.39 – 0.85)	<0.01
≥100	39 (100)	1528 (100)
Pathogenic APC	21 (54)	904 (59)	1.03 (0.49 – 2.21)	1.00
Biallelic MUTYH	1 (3)	98 (6)	0.31 (0.008 – 1.93)	0.38
Monoallelic MUTYH	0	17 (1)	1.50 (0 – 7.13)	1
APC p.I1307K	0	2 (0.1)	12.78 (0 – 108.54)	1
No APC or MUTYH variants	15 (38)	438 (29)	1.31 (061 – 2.73)	0.54

^*Adjusting for age at genetic testing