Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 20;11:605124. doi: 10.3389/fpsyt.2020.605124

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Chen, Goh, Chen and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The bi-phasic effects of olanzapine and clozapine on blood adiponectin levels over time. A single dose of olanzapine or clozapine had no influence on blood adiponectin levels. Treatment with olanzapine or clozapine up-regulates blood adiponectin levels acutely (t = 1–4 weeks), to compensate for the side effect on glucose homeostasis. Then, a new energy balance equilibrium is re-established during short-term treatment (4–12 weeks), returning blood adiponectin levels to the baseline. Finally, the failure of adiponectin up-regulation pushes blood adiponectin levels further below the baseline after long-term treatment (more than 3 months).