Figure 11.

The proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) induces the expression of CXCL16 and ADAM17 in Müller cells. Müller cells were left untreated or treated with TNF-α (50 ng/ml) for 24 h. Levels of CXCL16 were quantified in the culture media by ELISA. Protein expression of CXCL16, CXCR6, ADAM10, and ADAM17 in cell lysates was determined by Western blot analysis. Results are expressed as median (interquartile range) from three different experiments performed in triplicate. (*p < 0.05; Mann-Whitney test).