Table 3.

Multiple variable regression model using fold change for individual miRNAs in Placenta

	miR-126-3p	miR-130b-3p	miR-148a-3p	miR-29a-3p	miR-let-7a-5p
DM	a	1.156 [0.936, 1.429]	1.266 [0.961, 1.667]	1.188 [0.954, 1.479]	1.066 [0.815, 1.394]
Maternal age (Years)	0.998 [0.964, 1.033]	0.991 [0.974, 1.008]	0.985 [0.964, 1.007]	1.001 [0.983, 1.018]	1.001 [0.980, 1.022]
Maternal BMI (kg/m2)	1.008 [0.979, 1.038]	1.010 [0.995, 1.024]	1.007 [0.989, 1.026]	0.997 [0.982, 1.012]	1.007 [0.988, 1.026]
Gestational age (Weeks)	0.897 [0.687, 1.171]	1.015 [0.892, 1.156]	0.959 [0.813, 1.132]	1.010 [0.879, 1.162]	0.943 [0.800, 1.110]
Infant sex (M)	0.929 [0.616, 1.402]	1.160 [0.946, 1.422]	1.170 [0.897, 1.527]	0.824 [0.666, 1.018]	0.935 [0.725, 1.206]
Birth Weight (kg)	0.648 [0.377, 1.112]	0.807* [0.671, 0.971]	0.824 [0.652, 1.042]	0.789* [0.651, 0.958]	0.663* [0.526, 0.835]
Race/Ethnicity (Caucasian)	0.921 [0.615, 1.380]	0.951 [0.778, 1.164]	0.971 [0.747, 1.262]	0.962 [0.776, 1.193]	1.155 [0.894, 1.492]
Interactions:
DM: birth weight (kg)	3.388*a [1.571, 7.305]	NA	NA	NA	NA

Adjusted fold change [95%CI], each fold change adjusted for the above covariates

^*p value-<0.05, significant values are shown in bold

^aSimple effect of birth weight on miR-126 in the DM group

DM-n=33, Control-n=46