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. 2020 Jul 20;26(3):e12942. doi: 10.1111/adb.12942

FIGURE 4.

FIGURE 4

MORflox‐vGluT2cre mice have reduced oral oxycodone consumption but unchanged sucrose and quinine consumption. (A) Cre+ (KO) mice drank less oxycodone solution than Cre− (Ctrl) controls at 0.3, 1, and 3mg/ml concentrations [n = 16 (8M/8F) Cre+ (KO); n = 17 (9M/8F) Cre− (Ctrl)]. No sex differences were detected. (B) Cre+ (KO) mice showed less preference for oxycodone solution over water than Cre− (Ctrl) controls at 1 and 3mg/ml concentrations. No sex differences were detected. (C) There were no differences in sucrose consumption or (D) preference between genotypes [n = 16(9M/7F) Cre+ (KO), 17(8M/9F) Cre− (Ctrl)]. E) There were no statistically significant differences in quinine consumption or (F) preference between genotypes [n=16(9M/7F) Cre+ (KO), 17(8M/9F) Cre− (Ctrl)], although there was a trend at 0.1 mM quinine. Data presented here are collapsed across sex for clarity. Findings where sex differences were identified may be found in Figure S4 and Table S1. *p < 0.05; **p < 0.01; ***p < 0.001. # p = 0.06. Error bars indicate ± SEM. Cre+ (KO) = MORfloxvGluT2cre positive (+); Cre– (Ctrl) = MORflox‐vGluT2cre negative (−)