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. Author manuscript; available in PMC: 2021 May 30.
Published in final edited form as: Nat Microbiol. 2020 Nov 30;6(2):187–195. doi: 10.1038/s41564-020-00815-6

Figure 3: NP + GPC vaccination improves clinical scores and blood chemistry following CCHFV challenge.

Figure 3:

(A) Animals were comprehensively scored for evaluation of overt clinical disease and cumulative clinical scores are shown. Data shown as mean plus standard deviation. Statistical comparison was performed by two-way ANOVA with Sidak’s multiple comparison test at each time point. Day 6 PI P value = 0.0003. (B) At indicated time points platelets were enumerated in EDTA-treated whole-blood (normal range 300 – 500k/uL) and serum was evaluated for total protein (normal range 7.5 g/dL ±0.57), albumin (4.2 g/dL ±0.28) and aspartate aminotransferase (AST) (48.2IU/L ±36). Data is shown as mean plus standard deviation. Statistical comparison was performed between baseline values on day 0 and indicated time-point. N = 6 animals per group. Platelets, **** P < 0.0001, * P = 0.0129. Total Protein, **** P < 0.0001, ** P = 0.0027. Albumin, **** P < 0.0001, * P = 0.0131. AST, **** P < 0.0001, * P = 0.0280. P-values calculated with a two-tailed two-way ANOVA with Sidak’s multiple comparison test.