Table 1.
Summary of clinical data in 16 cases of Spitz neoplasms with ROS1 fusions
| Case | Age | Gender | Location | Diagnosis | Clinical impression | Surgical Treatment | SLNB | Metastasis | Follow up | Recurrence |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 34 | F | Right lower medial leg | Atypical Spitz tumor | Rule out atypical nevus vs Spitz nevus vs malignant melanoma; 6 x 4 mm color variated pink brown papule with radial streaming pattern at edges | Complete excision | No | No | 24 months | No |
| 2 | 37 | F | Left anterior medial thigh | Atypical Spitz tumor | 5.5 mm erythematous papule; dermatofibroma – check margins | Complete excision | No | No | 95 months | No |
| 3 | 28 | F | Left thigh | Atypical Spitz tumor | Cyst | Complete excision | No | No | 64 months | No |
| 4 | 13 | F | Left upper arm | Spitz nevus | Re-excision; rule out Spitz nevus | Complete excision | Not available | Not available | Not available | Not available |
| 5 | 20 | F | Left buttock | Spitz nevus | Intradermal nevus, rule out atypa | None | No | No | Not available | Not available |
| 6 | 6 | M | Right buttock | Spitz nevus | Changing nevus, rule out Spitz nevus | Complete excision | No | No | 35 months | No |
| 7 | 36 | F | Left shin | Atypical Spitz tumor | Melanocytic lesion, rule out atypical Spitz tumor | Not available | Not available | Not available | Not available | Not available |
| 8 | 12 | F | Right ear | Atypical Spitz tumor | None provided | Incisional biopsy without further re-excision | No | No | 4 months | Persistent tumor 4 months later |
| 9 | 15 | M | Left neck | Spitz nevus | Rule out Spitz nevus | Complete excision | No | No | 15 months | No |
| 10 | 15 | M | Right upper arm | Atypical Spitz tumor | Pyogenic granuloma versus hypertrophic scar | Complete excision | No | No | 11 months | No |
| 11 | 9 | M | Right ear | Spitz nevus | Nevus, rule out atypia | Complete excision | No | No | 10 months | No |
| 12 | 18 | M | Left mid back | Spitz nevus | Spitz nevus | Complete excision | No | No | 9 months | No |
| 13 | 17 | M | Left upper back | Desmoplastic Spitz nevus | Dermatofibroma | Complete excision | No | No | 5 months | No |
| 14 | 3 | M | Left ear | Spitz nevus | Rule out pyogenic granuloma | Complete excision | No | No | 13 months | No |
| 15 | 4 | F | Left knee | Spitz nevus | Rule out Spitz nevus | Complete excision | No | No | 13 months | No |
| 16 | 58 | F | Left arm | Atypical Spitz tumor | None provided | Complete excision | Yes, negative | No | 6 months | No |
| 17 | 6 | F | Abdomen | Desmoplastic Spitz nevus | None provided | Complete excision | No | No | Not available | No |
SLNB, sentinel lymph node biopsy; F, female; M, male;